Buffalo rookie quarterback EJ Manuel will miss "a few weeks" with a sprained ligament in his right knee.
The injury will not require surgery, Bills coach Doug Marrone said Friday, a day after a 37-24 loss in Cleveland.
Manuel was injured in the third quarter Thursday night, when he was hit by Browns safety Tashaun Gipson at the end of a 14-yard run.
Jeff Tuel, another rookie, replaced Manuel but was ineffective, completing 8 of 20 passes for 80 yards.
Marrone said the Bills will look into acquiring another quarterback and did not rule out the possibility of that player starting Buffalo's next game Oct. 13 at Cincinnati.
Also, receiver Stevie Johnson has a strained back muscle that is not expected to keep him out of action, Marrone said. Johnson left Thursday's game in the second quarter and did not return.