Orchard Park police responded to a fatal shooting late Saturday night in the camper lot at Ralph Wilson Stadium.
According to reports, a male sustained a self-inflicted gunshot wound. He died at the scene. His name was not released.
The camper lot was filled to capacity at the time of the shooting. The Buffalo Bills host the Indianapolis Colts at the stadium in the season opener.
"This is an isolated incident," Orchard Park Police Chief Mark Pacholec said at a news conference.
Pacholec said the incident would have no impact on Sunday's game.